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Lot I-10-7, D7 Street, Saigon Hi-Tech Park, Tang Nhon Phu Ward, Thu Duc City, HCMC
(+84) 28 7301 3688
(+84) 28 7301 3688
Info@wembleymed.com.vn
Info@wembleymed.com.vn

Pre-Filled Syringes vs. Traditional Method

Author

Dr. Nguyen Van Phuc, Specialist Level II

  • Member of the WEMBLEY MEDICAL Professional Advisory Team
  • Former Deputy Director in Charge of Professional Affairs - District 12 Medical Center
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Author

The research paper "Comparing Single-Use Pre-Filled Saline Syringes with the Traditional Method (Saline Bottle + Syringe + Needle) in Terms of Safety, Convenience, Cost-Effectiveness, and Productivity" was published by Dr. Nguyen Van Phuc, CKII, based on international clinical evidence and guidelines issued by Vietnam's Ministry of Health. The paper presents a comprehensive analysis demonstrating the clear advantages of pre-filled syringes (PFS) over the traditional manual compounding technique.

1. Clinical research & medical literature review

Abstract

Objective: To provide scientific evidence from clinical studies (RCTs, meta-analyses) and synthesized guidelines from reputable health organizations (WHO, CDC, INS, Vietnam's Ministry of Health) comparing the effectiveness of pre-filled saline syringes (PFS) versus the traditional manual compounding method.

Methods: A systematic review and meta-analysis of multicenter clinical data and randomized controlled trials from 2013 to 2025 (including studies by Ceylan, Saliba, Benhamou, and others), focusing on the following criteria: infection rates, catheter failure, procedure time, and healthcare cost-effectiveness.

Results:

  • PFS reduces the rate of central line-associated bloodstream infections (CLABSI) by up to 77% and lowers the rate of catheter-related bloodstream infections (CRBSI) by nearly 2.5-fold (from 6.3% to 2.7%, P = 0.016). The needleless design completely eliminates the risk of occupational needlestick injuries.
  • A multicenter study of 3,853 catheters showed that PFS reduced the catheter failure rate from 57% to 43.4% (p < 0.001)
  • The manual compounding group violated Aseptic Non-Touch Technique (ANTT) protocols in up to 72.3% of cases, while the PFS group maintained strict error control.
  • Flushing procedure time dropped significantly from 86 seconds to 35.2 seconds. PFS reduces nursing resources allocated to compounding and syringe management by up to 85%.
  • The manual method results in solution wastage ranging from 57% to 86% (atropine, epinephrine, etc.), whereas wastage with PFS is 0%. Economic analysis demonstrates that PFS saves healthcare systems millions of USD through reduced medication errors and infections.

Conclusion: Single-use pre-filled saline syringes offer comprehensive benefits and are recommended by leading organizations such as INS, CDC, and WHO as a complete replacement for drawing solution from shared multi-dose vials/bottles. In Vietnam, the transition to PFS should be prioritized in key departments such as ICU, Emergency, Pediatrics, and Oncology.

Keywords

Pre-filled saline syringes (PFS), catheter flushing, catheter-related bloodstream infections (CRBSI/CLABSI), injection safety, nursing workflow optimization.

2. WEMSYIN pre-filled flush saline syringes: The leading solution for new clinical standards

Backed by solid real-world medical evidence, the shift toward single-dose pre-filled systems is becoming an essential requirement for infection control in modern hospitals. Responding to this pressing need within Vietnam's healthcare system, WEMBLEY MEDICAL is proud to be the pioneering manufacturer of WEMSYIN Pre-filled Saline Flush Syringes (PFS) in Vietnam.

The product is used to flush peripheral intravenous catheters (PIVCs), peripherally inserted central catheters (PICCs), central venous catheters (CVCs), and subcutaneous infusion ports, maintaining line integrity and preventing occlusion.

Technical & Clinical standards

WEMSYIN Pre-filled Saline Syringes offer a safe, convenient, time-saving solution that enhances the efficiency of maintaining IV lines and catheter care in hospitals and clinics.

Researched and designed by WEMBLEY MEDICAL, the product is manufactured on automated production lines within a Class 100,000 cleanroom and controlled by an internationally recognized quality management system, offering the following outstanding advantages:

  • Fully sterile, single-use, ensuring maximum safety for both healthcare professionals and patients.
  • Medical-grade PP plastic material, ensuring the solution volume remains stable and accurate over time.
  • Luer-lock connector generating an injection pressure of ≥ 19.75 psi, enabling effective flushing of all catheter types.
  • Multiple volume options: 3 mL, 5 mL, 10 mL, offering flexibility for different needs.

Advanced Sterilization Technology & Specialized Product Classification

The product is manufactured on next-generation automated production lines within a certified cleanroom, strictly controlled by internationally recognized certification systems: ISO 13485:2016, GMP, and CE Marking.

Applying advanced steam sterilization and ETO (Ethylene Oxide) sterilization technologies, WEMBLEY MEDICAL offers two product lines to flexibly meet clinical requirements:

  • WEMSYIN XS (Dual Sterilization): Provides complete sterility for both the internal solution and the external surface of the syringe. Specifically designed for high-sterility environments such as operating rooms (OR), Intensive Care Units (ICU), or procedures involving central venous catheters.
  • WEMSYIN SP (Internal Sterilization): Ensures complete sterility of the 0.9% NaCl solution and the internal fluid pathway. Suitable for environments that do not require surface sterility, intended for routine flushing/cleaning of peripheral IV lines in general hospital departments.

Clinical Recommendation: The product is especially suitable and recommended as a priority choice for Intensive Care Units (ICU), Emergency Departments, Oncology, Neonatal/Pediatric units, and hemodialysis centers.

For detailed product information, please contact our Hotline at 028 7301 3688 for prompt support.

Rated 3.5/5 based on 11 customer reviews
WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe
WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe WEMSYIN Pre-filled Saline Flush Syringe
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WEMSYIN Pre-filled Saline Flush Syringe

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WEMSYIN Pre-filled Saline Flush Syringe is a pre-filled syringe used to flush in-situ peripheral intravenous catheters (PIVCs), peripherally inserted central catheters (PICCs), central venous catheters (CVCs), and implanted venous access ports to maintain integrity and prevent blockages. The saline solution in the syringe helps to clear blood, medication residue, or debris from the tubing. This process helps prevent clots, improves flow, and reduces the risk of infection.

Product features:

  • Single-use, sterile medical device, individually packaged.
  • Made from medical grade Polypropylene (PP), ensuring stable solution volume over long periods of time.
  • Luer lock tip, syringe can generate pressure ≥19.75 psi.
  • Available in multiple volumes: 3mL, 5mL, 10mL.
  • Effectively flushes IV lines and supports optimal catheter performance.
  • Sterile 0.9% saline solution: each mL contains 9mg of Sodium Chloride, with a pH range of 4.5 to 7.0.

Source: "Comparing Single-Use Pre-Filled Saline Syringes with the Traditional Method (Saline Bottle + Syringe + Needle) in Terms of Safety, Convenience, Cost-Effectiveness, and Productivity," authored by Dr. Nguyen Van Phuc.